{"abstracts":[{"sha1":"04fee11402119e0f1258627cfcdd3df29df7624a","content":"Since hyaluronic acid (HA) receptor such as CD44 is
\nover-expressed at sites of cancer cells, HA can be used as a targeting
\nvehicles for anti-cancer drugs. The aim of this study is to synthesize
\nblock copolymer composed of hyaluronic acid and
\npoly(ε-caprolactone) (HAPCL) and to fabricate polymeric micelles for
\nanticancer drug targeting against CD44 receptor of tumor cells.
\nChemical composition of HAPCL was confirmed using 1H NMR
\nspectroscopy. Doxorubicin (DOX) was incorporated into polymeric
\nmicelles of HAPCL. The diameters of HAPHS polymeric micelles
\nwere changed around 80nm and have spherical shapes. Targeting
\npotential was investigated using CD44-overexpressing. When
\nDOX-incorporated polymeric micelles was added to KB cells, they
\nrevealed strong red fluorescence color while blocking of CD44
\nreceptor by pretreatment of free HA resulted in reduced intensity,
\nindicating that HAPCL polymeric micelles have targetability against
\nCD44 receptor.","mimetype":"text/plain","lang":"en"}],"refs":[],"contribs":[{"index":0,"raw_name":"Jong Ho Hwang","given_name":"Jong Ho","surname":"Hwang","role":"author"},{"index":1,"raw_name":"Dae Hwan Kang","given_name":"Dae Hwan","surname":"Kang","role":"author"},{"index":2,"raw_name":"Young-IL Jeong","role":"author"}],"license_slug":"CC-BY","language":"en","publisher":"Zenodo","ext_ids":{"doi":"10.5281/zenodo.1087285"},"release_year":2013,"release_date":"2013-07-26","release_stage":"published","release_type":"article-journal","webcaptures":[],"filesets":[],"files":[{"release_ids":["c7me74d2ivanxmpz6eq2t2wryi"],"mimetype":"application/pdf","urls":[{"url":"https://zenodo.org/record/1087285/files/16466.pdf","rel":"repository"},{"url":"https://web.archive.org/web/20200226081628/https://zenodo.org/record/1087285/files/16466.pdf","rel":"webarchive"}],"sha256":"f8f2bfff37d1be0253c1353256769775412cacbf7b6e59c56cf9f48c28f16607","sha1":"529aa9d1e94ca84b183a3e8df4abe4b339884577","md5":"7c6ba94efcc5905f34484998131f06bd","size":760969,"revision":"8dabbed6-72eb-4342-b0fe-47cdf348dde6","ident":"65y25l64cjfvjd5cx2xkx6nyzq","state":"active"}],"work_id":"bil5jnez3vgthkcyb463xr27de","title":"Biorecognizable Nanoparticles Based On Hyaluronic Acid/Poly(Ε-Caprolactone) Block Copolymer","state":"active","ident":"c7me74d2ivanxmpz6eq2t2wryi","revision":"897191a7-e411-46c3-bd50-30e5c6441166","extra":{"datacite":{"license":[{"rights":"Creative Commons Attribution 4.0","rightsUri":"https://creativecommons.org/licenses/by/4.0"},{"rights":"Open Access","rightsUri":"info:eu-repo/semantics/openAccess"}],"metadataVersion":1,"relations":[{"relatedIdentifier":"10.5281/zenodo.1087284","relatedIdentifierType":"DOI","relationType":"IsVersionOf"}],"resourceType":"Journal article","resourceTypeGeneral":"Text","subjects":[{"subject":"Hyaluronic acid"},{"subject":"CD44 receptor"},{"subject":"biorecognizable\nnanoparticles"},{"subject":"block copolymer."}]},"release_month":7}}